Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles.
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منابع مشابه
Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles.
The endothelium of mouse pial arterioles was injured in situ with a light/dye technique. The response of the arterioles to acetylcholine or to bradykinin was compared before and after the injury. All vessels failed to dilate after injury. In fact the predominant response now became constriction. The injured vessels were still capable of dilating to papaverine. Uninjured vessels continued to dil...
متن کاملEndothelium-dependent constriction demonstrated in vivo in mouse cerebral arterioles.
Endothelium-dependent constriction in mouse pial arterioles was demonstrated by testing contractile responses before and after endothelial injury. All responses were monitored at the same site as the injury. Injury was produced in vivo by exposing an arteriole on the brain surface to the beam of a 6-mW helium-neon laser after first sensitizing the microvascular bed to the laser energy by inject...
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Bradykinin relaxes arterioles on the brain's surface. This response is endothelium-dependent. The data presented here confirm the hypothesis that hydroxyl free radical mediates this response and may be the endothelium-dependent relaxing factor for bradykinin in this microvascular bed. The response to a locally applied bolus of bradykinin (80 micrograms/ml) was monitored by intravital TV microsc...
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ژورنال
عنوان ژورنال: Stroke
سال: 1986
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.17.3.494